Effects of High-intensity Interval Training Combined With Resistance Training in Patients With Systemic Lupus Erythematosus

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this study is to evaluate the safety and effects of high-intensity interval training (HIIT) combined with resistance training in patients with systemic lupus erythematosus

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• ≥18 years old

• Fulfilment of the 1982 American College of Rheumatology (ACR) criteria; or 2012 Systemic Lupus International Collaborating Clinics (SLICC/ACR-Damage Index (DI)) classification criteria; or EULAR/ACR criteria; or patients that have received the diagnosis SLE on clinical grounds

• Low to moderate disease activity, for example defined as a score of ≤5 in the clinical version of the SLE Disease Activity Index 2000 (SLEDAI-2K), i.e., excluding the serological descriptors (anti-dsDNA positivity and low complement levels)

• Low/minimal or no organ damage, for example defined as a score of ≤3 in the SLICC/ACR DI

• Stable pharmacological treatment

• The ability to perform a maximal ergometercycle exercise test

• Be able to read and understand Swedish

Locations
Other Locations
Sweden
Carina Boström
RECRUITING
Stockholm
Contact Information
Primary
Carina M Boström, Dr
carina.bostrom@ki.se
046 0722006321
Backup
Ioannis Parodis, Dr
ioannis.parodis@ki.se
046 0722321322
Time Frame
Start Date: 2022-11-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 40
Treatments
Experimental: High-intensity interval training (HIIT) combined with resistance training
Patients with SLE will undergo supervised HIIT on an ergometercycle 4 x 4 minutes interval (85-90% of maximal heart rate in 4 minutes and lower intensity for another 4 minutes etc). The HIIT is combined with resistance exercises for upper and lower extremity. In total the supervised training takes around 50 minutes per occasion and will be performed 2 times/week, for 3 months. In addition, the patients will exercise, according to the program, by themselves once a week.~Between months 3 and 6 the patients exercise by themselves, 3 times/week, with video-call/telephone support from a physiotherapist once a week.
No_intervention: Control group
Both the control group and the HIIT combined with resistance training group receive standard care.
Related Therapeutic Areas
Sponsors
Collaborators: County Council of Norrbotten, Sweden, Region Örebro County, Karolinska University Hospital, Swedish Rheumatism Association
Leads: Karolinska Institutet

This content was sourced from clinicaltrials.gov